Sage Athletics

Jennifer Freytag, Ph.D.
The Sage Colleges' Faculty Athletic Representative

Associate Professor, Biology

Science Building, Albany
518-292-1754
freytj@sage.edu

Research Interests

• Mechanisms of tumor metastasis
• Epithelial-to-mesenchymal transition in cancer cells
• Effects of growth factors on cell migration
• Gene expression changes in cancer development

Publications

Czekay RP, Wilkins-Port CE, Higgins SP, Freytag J, Overstreet JM, Klein RM, Higgins CE, Samarakoon R, and Higgins PJ.  “PAI-1: An integrator or cell signaling and migration.” International Journal of Cell Biology.  2011.  2011: 562481.

Wilkins-Port CE, Freytag J, Higgins SP, and Higgins PJ.  “PAI-1: a multifunctional SERPIN with complex roles in cell signaling and migration.”  Cell Communication Insights.  2010. 3:1-10.

Freytag J, Wilkins-Port CE, Higgins CE, Higgins SP, Samarakoon R, and Higgins PJ.  “PAI-1 mediates the TGF-b1+EGF-induced “scatter”-response in transformed human keratinocytes.”  Journal of Investigative Dermatology.  2010.  130: 2179-2190.

Freytag J, Wilkins-Port CE, Higgins CE, Carlson JA, Noel A, Foidart JM, Higgins SP, Samarakoon R, and Higgins PJ.  “PAI-1 regulates the invasive phenotype in human cutaneous squamous cell carcinoma.” Journal of Oncology.  2009.  Article ID 963209.

Higgins SP, Samarakoon, R, Higgins, CE, Freytag J, Wilkins-Port, CE, and Higgins, PJ.  “TGF-b1-induced expression of the anti-apoptotic PAI-1 protein requires EGFR-signaling.” Cell Communication Insights.  2009.  2: 1-11.

Wilkins-Port CE, Higgins CE, Freytag J, Higgins SP, Carlson JA, and Higgins PJ.  “PAI-1 is a critical upstream regulator of the TGF-β1/EGF-induced invasive phenotype in mutant p53 human cutaneous squamous cell carcinoma.”  Journal of Biomedicine and Biotechnology.  2007.  Article ID 85208.

Invited Presentation

“PAI-1 is an early event in and is required for TGF- β1+EGF-induced phenotypic plasticity of ras-transformed human keratinocytes.”  Minisymposium on Tumor Biology: Mechanisms of Tumor Progression, Invasion, and Metastasis, American Association for Cancer Research (AACR) 100th Annual Meeting, Denver, CO. April 2009. 

Abstracts/Posters

Freytag J, Samarakoon R, and Higgins PJ.  “TGF-β1-induced EGFR transactivation and subsequent PAI-1 expression requires ADAM17 and src activity.” Translational Oncology Research Symposium: Transforming Basic Science into Clinical Practice.  Albany, NY. September 2010.

Freytag J, Higgins CE, Saramarkoon R, Higgins SP, Wilkins-Port CE, and Higgins PJ.  “PAI-1 expression is an early event in and is necessary for growth factor-induced epithelial plasticity of human keratinocytes and requires TGF-b1-induced transactivation of EGFR.”  Translational Symposium: Transforming Basic Science into Clinical Practice.  Albany NY.  October 2009.

Freytag J, Higgins CE, Samarakoon R, Higgins SP, and Higgins PJ.  “Involvement of PAI-1 in growth factor-induced plasticity of pre-malignant human keratinocytes.”  Translational Symposium: Transforming Basic Science into Clinical Practice.  Albany, NY.  September 2008.

Spaulding C, Freytag J, Kutz SM, Higgins PJ.  “PAI-1 Expression is critical for TGF-b1+EGF-stimulated cell migration and wound closure of human keratinocytes.” North East Regional Sigma Xi Conference.  Ithaca, NY.  April 2008.

Cervone C, Kutz SM, Freytag J, Higgins PJ.  “TGF-β1-stimulated transactivation of the EGF receptor is required for PAI-1 Expression.”  North East Regional Sigma Xi Conference.  Ithaca, NY.  April 2007.